Rheumatoid factor and immune networks.
DA Carson, PP Chen, RI Fox, TJ Kipps… - Annual review of …, 1987 - europepmc.org
Rheumatoid factors represent a normal component of the immune network. The
autoantibodies promote complement fixation and clearance of immune complexes. They …
autoantibodies promote complement fixation and clearance of immune complexes. They …
Antibody multispecificity in immunoassay interference
SS Levinson - Clinical biochemistry, 1992 - Elsevier
Recent findings indicate that many endogenous antibodies exhibit multispecificity. These
antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere …
antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere …
An enzyme-linked immunosorbent assay (ELISA) for prostate-specific antigen
LI Stowell, LE Sharman, K Hamel - Forensic science international, 1991 - Elsevier
A sandwich ELISA for human prostate-specific antigen (PSA) is described. Optimal assay
conditions, resulting in a sensitive assay with a low background, are presented. The method …
conditions, resulting in a sensitive assay with a low background, are presented. The method …
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
V Radoux, PP Chen, JA Sorge… - The Journal of …, 1986 - europepmc.org
The full-length gene that encodes the light chain variable regions of an idiotypically related
group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The …
group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The …
Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and …
MM Newkirk, RA Mageed, R Jefferis, PP Chen… - The Journal of …, 1987 - rupress.org
Evidence derived from the complete amino acid sequences of the variable regions of both
the heavy and light chains of two members (BOR and KAS) of the Wa idiotypic family of …
the heavy and light chains of two members (BOR and KAS) of the Wa idiotypic family of …
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B …
MJ Shlomchik, DA Nemazee, VL Sato… - The Journal of …, 1986 - rupress.org
The nucleotide sequences of heavy and light chains from 10 monoclonal IgM anti-IgG1 (RF)
antibodies were determined and reported here as translated amino acid sequences. Only …
antibodies were determined and reported here as translated amino acid sequences. Only …
Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes.
A Davidson, A Manheimer-Lory… - The Journal of …, 1990 - Am Soc Clin Investig
We report the molecular characterization of 2A4, an IgG, DNA-binding antibody bearing the
3I and F4 idiotypes which are associated with anti-DNA antibodies in serum of patients with …
3I and F4 idiotypes which are associated with anti-DNA antibodies in serum of patients with …
Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.
GJ Silverman, RD Goldfien, P Chen… - The Journal of …, 1988 - Am Soc Clin Investig
Rheumatoid factors (RFs) in humans have been studied intensively because of their
association with autoimmune and lymphoproliferative diseases. Many human IgM-RFs …
association with autoimmune and lymphoproliferative diseases. Many human IgM-RFs …
Rheumatoid factor
PP Chen, S Fong, DA Carson - Rheumatic Disease Clinics of North …, 1987 - Elsevier
Many human RF-associated crossreactive idiotypes (CRIs) have been defined. Since these
CRIs probably are the phenotypic markers of Ig variable region genes, the data suggest that …
CRIs probably are the phenotypic markers of Ig variable region genes, the data suggest that …
Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies.
PP Chen, K Albrandt, NK Orida… - Proceedings of the …, 1986 - National Acad Sciences
The role of immunoglobulin structural genes in the generation of autoantibodies in humans
has not been elucidated. Human monoclonal IgM anti-IgG autoantibodies (rheumatoid …
has not been elucidated. Human monoclonal IgM anti-IgG autoantibodies (rheumatoid …