One of the key features of the immune system is its extraordinary capacity to discriminate
between self and non-self and to respond accordingly. Several molecular interactions allow …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Bovine respiratory disease complex (BRDC) is a multifactorial disease of cattle which
presents as bacterial and viral pneumonia. The causative agents of BRDC work in synergy …

Complement factor H is a major regulator of the alternative pathway of the complement
system. The factor H-related proteins are less characterized, but recent data indicate that …

Non‐typeable H aemophilus influenzae is an opportunistic pathogen of the human upper
respiratory tract and is often found to cause inflammatory diseases that include sinusitis …

Nonulosonic acids (NulOs) are a diverse family of 9-carbon α-keto acid sugars that are
involved in a wide range of functions across all branches of life. The family of NulOs includes …

Novel therapies are urgently needed to combat the global threat of multidrug-resistant
pathogens. Complement forms an important arm of innate defenses against infections. In …

ABSTRACT Although nontypeable Haemophilus influenzae (NTHi) is a human-specific
nasopharyngeal commensal bacterium, it also causes upper respiratory tract infections in …

The incidence of Vibrio vulnificus infections, with high mortality rates in humans and aquatic
animals, has escalated, highlighting a significant public health challenge. Currently, reliable …

Sialic acids are found on all vertebrate cell surfaces and are part of a larger class of
molecules known as nonulosonic acids. Many bacterial pathogens synthesize related nine …