Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

Abstract Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the
immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of …

Leukocyte migration from the blood into tissues is vital for immune surveillance and
inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell …

Infection with Neisseria gonorrhoeae can trigger an intense inflammatory response, yet
there is little specific immune response or development of immune memory. In addition …

Vascular smooth muscle cells (SMCs) are present in several phenotypic states in blood
vessels. They show a high degree of plasticity, undergoing rapid and reversible phenotypic …

The regulation of protein tyrosine phosphatase (PTPase) SHP-2 is proposed to involve
tyrosine phosphorylation on two tail tyrosine residues. Using" expressed protein ligation" …

Interest in the diverse biology of protein tyrosine phosphatases that are encoded by more
than 100 genes in the human genome continues to grow at an accelerated pace. In …

Ectodomain shedding has emerged as an important regulatory step in the function of
transmembrane proteins. Intercellular adhesion molecule-1 (ICAM-1), an adhesion receptor …

Adhesion molecules are known to mediate cell–cell interactions, particularly those between
T cells and antigen-presenting or target cells. Recent studies identified ICAM-1 as a co …

Stable adhesion of leukocytes to endothelium is crucial for transendothelial migration (TEM)
of leukocytes evoked during inflammatory responses, immune surveillance, and homing and …