Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

It is well established that bile acids play important roles in lipid metabolism. In recent
decades, bile acids have also been shown to function as signaling molecules via interacting …

Bile acids are signaling molecules that coordinately regulate metabolism and inflammation
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …

Bile acids are a group of chemically different steroids generated at the host/microbial
interface. Indeed, while primary bile acids are the end-product of cholesterol breakdown in …

The intracellular nuclear receptor farnesoid X receptor and the transmembrane G protein-
coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or …

The hormonal metabolite of vitamin D, 1α, 25-dihydroxyvitamin D 3 (1, 25D), initiates
biological responses via binding to the vitamin D receptor (VDR). When occupied by 1, 25D …

The incidence and/or prevalence of health problems associated with endocrine‐disruption
have increased. Many chemicals have endocrine‐disrupting properties, including bisphenol …

The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …

▪ Abstract The synthesis and excretion of bile acids comprise the major pathway of
cholesterol catabolism in mammals. Synthesis provides a direct means of converting …

The intestine is the largest peripheral lymphoid organ in animals, including humans, and
interacts with a vast array of microorganisms called the gut microbiota. Comprehending the …