Impact of natural products on developing new anti-cancer agents

GM Cragg, PG Grothaus, DJ Newman - Chemical reviews, 2009 - ACS Publications
Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

The thioredoxin system in cancer

ESJ Arner, A Holmgren - Seminars in cancer biology, 2006 - Elsevier
Thioredoxin (Trx), NADPH and thioredoxin reductase (TrxR) comprise a thioredoxin system
which exists in nearly all living cells. It functions in thiol-dependent thiol-disulfide exchange …

[图书][B] Anticancer agents from natural products

GM Cragg, DGI Kingston, DJ Newman - 2005 - taylorfrancis.com
Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Targeting the thioredoxin system as a strategy for cancer therapy: Miniperspective

M Bian, R Fan, S Zhao, W Liu - Journal of medicinal chemistry, 2019 - ACS Publications
Thioredoxin reductase (TrxR) participates in the regulation of redox reactions in organisms.
It works mainly via its substrate molecule, thioredoxin, to maintain the redox balance and …

On the potential of thioredoxin reductase inhibitors for cancer therapy

S Urig, K Becker - Seminars in cancer biology, 2006 - Elsevier
Thioredoxin reductase (TrxR)-as part of a major thiol regulating system-allows redox
metabolism to adjust to cellular requirements. Therefore, changes at the redox level reflect …

Antioxidant enzymes and their contributions to biological control potential of fungal insect pathogens

LB Zhang, MG Feng - Applied microbiology and biotechnology, 2018 - Springer
Filamentous fungal insect pathogens represent a source of biological insecticides and
acaricides formulated using intact cells, such as conidia or other spores. These …

Small molecule inhibitors of mammalian thioredoxin reductase

W Cai, L Zhang, Y Song, B Wang, B Zhang… - Free Radical Biology …, 2012 - Elsevier
Mammalian thioredoxin reductases (TrxRs) are a family of NADPH-dependent flavoproteins
with a penultimate selenocysteine residue at the carboxy-terminus. Besides their native …

Thioredoxin: friend or foe in human disease?

A Burke-Gaffney, MEJ Callister, H Nakamura - Trends in pharmacological …, 2005 - cell.com
Thioredoxin (Trx), a small, ubiquitous thiol [sulfydryl (-SH)] protein, is one of the most
important regulators of reduction–oxidation (redox) balance and, thus, redox-controlled cell …

[HTML][HTML] SERD-NHC-Au (I) complexes for dual targeting ER and TrxR to induce ICD in breast cancer

Y Lu, X Sheng, C Liu, Z Liang, X Wang, L Liu… - Pharmacological …, 2023 - Elsevier
The development of selective estrogen receptor degraders (SERDs) has brought new ideas
for the clinical treatment of ER-positive advanced breast cancer. The successful application …

Guanidines in organic synthesis

T Ishikawa, T Kumamoto - Synthesis, 2006 - thieme-connect.com
Thieme E-Journals - Synthesis / Full Text DE EN Home Products Journals Books Book Series
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