The original concept behind map-based or positional cloning was to find a DNA marker
linked to a gene of interest, and then to 'walk'to the gene via overlapping clones (eg cosmids …

▪ Abstract During the past four years, significant progress has been made in identifying the
molecular components of the mammalian circadian clock system. An autoregulatory …

The tau mutation is a semidominant autosomal allele that dramatically shortens period
length of circadian rhythms in Syrian hamsters. We report the molecular identification of the …

The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism
(Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like …

MUTATIONS at the nude locus of mice and rats disrupt normal hair growth and thymus
development1, 2, causing nude mice and rats to be immune-deficient. The mouse nude …

Detection of differentially regulated genes has been severely hampered by technical
limitations. In an effort to overcome these problems, the PCR-coupled subtractlve process of …

Behavioral and pharmacological responses of selectively bred and inbred rodent lines have
been analyzed to elucidate many features of drug sensitivity and the adverse effects of …

Axon pathfinding relies on the ability of the growth cone to detect and interpret guidance
cues and to modulate cytoskeletal changes in response to these signals. We report that the …

In Part II of his review of the basis of autoimmunit~: Argyrios N. Theofilopoulos summarizes
current knowledge on the genetic factors that contribute to autoimmune disease …

The EWS/FLI-1 fusion gene results from the 11; 22 chromosomal translocation in Ewing's
sarcoma. The product of the gene is one of a growing number of structurally altered …