Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
Advances in nanomaterial-based targeted drug delivery systems
X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …
Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase …
AM Sonabend, A Gould, C Amidei, R Ward… - The Lancet …, 2023 - thelancet.com
Background Low-intensity pulsed ultrasound with concomitant administration of intravenous
microbubbles (LIPU-MB) can be used to open the blood–brain barrier. We aimed to assess …
microbubbles (LIPU-MB) can be used to open the blood–brain barrier. We aimed to assess …
Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications
Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh
piezoelectric coefficient and have an appealing safety profile for medical implant …
piezoelectric coefficient and have an appealing safety profile for medical implant …
Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment
The treatment of glioblastoma has limited clinical progress over the past decade, partly due
to the lack of effective drug delivery strategies across the blood-brain-tumor barrier …
to the lack of effective drug delivery strategies across the blood-brain-tumor barrier …
Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
[HTML][HTML] Blood–brain barrier modulation to improve glioma drug delivery
H Luo, EV Shusta - Pharmaceutics, 2020 - mdpi.com
The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …
Focused ultrasound and microbubbles-mediated drug delivery to brain tumor
The presence of blood–brain barrier (BBB) and/or blood–brain–tumor barriers (BBTB) is one
of the main obstacles to effectively deliver therapeutics to our central nervous system (CNS); …
of the main obstacles to effectively deliver therapeutics to our central nervous system (CNS); …