Stereoselective semi‐hydrogenations of alkynes by first‐row (3d) transition metal catalysts

BJ Gregori, MOWS Schmotz… - …, 2022 - Wiley Online Library
The chemo‐and stereoselective semi‐hydrogenation of alkynes to alkenes is a fundamental
transformation in synthetic chemistry, for which the use of precious 4d or 5d metal catalysts …

Recent advances in asymmetric total synthesis of prostaglandins

H Peng, FE Chen - Organic & biomolecular chemistry, 2017 - pubs.rsc.org
Prostaglandins (PGs) are a series of hormone-like chemical messengers and play a critical
role in regulating physiological activity. The diversified therapeutic activities and complex …

A concise and scalable chemoenzymatic synthesis of prostaglandins

Y Yin, J Wang, J Li - Nature Communications, 2024 - nature.com
Prostaglandins have garnered significant attention from synthetic chemists due to their
exceptional biological activities. In this report, we present a concise chemoenzymatic …

Total synthesis endeavors and their contributions to science and society: A personal account

KC Nicolaou, S Rigol, R Yu - CCS Chemistry, 2019 - chinesechemsoc.org
The advent of organic synthesis in the 19th century, serendipitous as it was, set in motion a
revolution in science that continues to evolve into increasing levels of sophistication and to …

Concise Syntheses of Δ12-Prostaglandin J Natural Products via Stereoretentive Metathesis

J Li, TS Ahmed, C Xu, BM Stoltz… - Journal of the American …, 2018 - ACS Publications
Δ12-Prostaglandin J family is recently discovered and has potent anticancer activity.
Concise syntheses of four Δ12-prostaglandin J natural products (7–8 steps in the longest …

Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of Δ12‐Prostaglandin J3

A Pelšs, N Gandhamsetty, JR Smith… - … A European Journal, 2018 - Wiley Online Library
Re‐investigation of the l‐proline catalyzed double aldol cascade dimerization of
succinaldehyde for the synthesis of a key bicyclic enal intermediate, pertinent in the field of …

A General Catalyst Controlled Route to Prostaglandin F2α

L Cunningham, S Mishra, L Matthews… - Organic Letters, 2022 - ACS Publications
We report a general, catalyst-controlled route to prostaglandin F2α and its analogues. The
approach uses a Rh-catalyzed dynamic kinetic asymmetric Suzuki–Miyaura coupling …

Synthesis and Biological Investigation of Δ12-Prostaglandin J312-PGJ3) Analogues and Related Compounds

KC Nicolaou, KK Pulukuri, S Rigol… - Journal of the …, 2016 - ACS Publications
A series of Δ12-prostaglandin J3 (Δ12-PGJ3) analogues and derivatives were synthesized
employing an array of synthetic strategies developed specifically to render them readily …

Cross-Conjugated Cyclopentenone Prostaglandins. Recent Advances

VV Loza, AM Gimazetdinov, MS Miftakhov - Russian Journal of Organic …, 2018 - Springer
The review covers the literature on the total synthesis of cross-conjugated cyclopentenone
prostaglandins (PGs), published from 2000 until present. In view of the specific features …

Some aspects of the synthesis and modification of cross-conjugated cyclopentenone prostaglandins

AM Gimazetdinov, VV Zagitov, ZR Makaev… - Russian Chemical …, 2023 - Springer
The review summarizes the results of our studies on the synthesis of cross-conjugated
cyclopentenone prostaglandins and their analogs. The data on the cytotoxicity of selected …