Individual cells are basic units of life. Despite extensive efforts to characterize the cellular
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …

Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

The development of pancreatic islet endocrine cells is a tightly regulated process leading to
the generation of distinct cell types harbouring different hormones in response to small …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …

Transgene driven expression of Escherichia coli nitroreductase (NTR1. 0) renders animal
cells susceptible to the antibiotic metronidazole (MTZ). Many NTR1. 0/MTZ ablation tools …

Animal development proceeds in the presence of intimate microbial associations, but the
extent to which different host cells across the body respond to resident microbes remains to …

Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other
pancreatic cells raises the questions of the efficiency of the process and of the functionality …

The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-
3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These …

Pancreatic ε-cells producing ghrelin are one type of endocrine cell found in islets, which
have been shown to influence other intra-islet cells, especially in regulating the function of β …