Introduction: In multi-objective drug design, optimization gains importance, being upgraded
to a discipline that attracts its own research. Current strategies are broadly classified into …

Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first
genetic circuits─ the repressilator and the toggle switch─ were designed and implemented …

Evolution repeatedly converges on only a few regulatory circuit designs that achieve a given
function. This simplicity helps us understand biological networks. However, why so few …

Transcription factor-based biosensors naturally occur in metabolic pathways to maintain cell
growth and to provide a robust response to environmental fluctuations. Extended metabolic …

The reproduction of emergent behaviors in nature using reaction networks is an important
objective in synthetic biology and systems chemistry. Herein, the first experimental …

Recent progress in synthetic biology allows the construction of dynamic control circuits for
metabolic engineering. This technology promises to overcome many challenges …

Synthetic biologists have made great progress over the past decade in developing methods
for modular assembly of genetic sequences and in engineering biological systems with a …

With the progress of the times and the development of science, industrial clusters have been
regarded by all countries in the world as one of the important ways to enhance regional …

In this work we consider Pareto optimality for automated design in synthetic biology. We
present a generalized framework based on a mixed-integer dynamic optimization …

Stochastic fluctuations in gene expression trigger both beneficial and harmful consequences
for cell behavior. Therefore, achieving a desired mean protein expression level while …