NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of
the noncanonical NF-κB pathway, has important roles in regulating immunity and …

Since the discovery of the nuclear factor kappa B (NF-ĸB) transcription factor 36 years ago,
many studies have linked the NF-ĸB signaling pathway to pathological and physiological …

Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T
cell persistence, especially for CAR T cells that target CD19+ hematologic malignancies. 4 …

Calcium phosphate-based materials (CaP) have been widely used as bone graft substitutes
with a decent osseointegration. However, the mechanism whereby cells function and repair …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Whether bone marrow modulates systemic metabolism remains unknown. Our recent study
suggested that myeloid-derived growth factor (MYDGF) improves insulin resistance. Here …

Treatment of lung cancer with conventional therapies, which include radiation, surgery, and
chemotherapy results in multiple undesirable adverse or side effects. The major clinical …

A mesenchymal tumor phenotype associates with immunotherapy resistance, although the
mechanism is unclear. Here, we identified FBXO7 as a maintenance regulator of …

Purpose Nonalcoholic fatty liver disease (NAFLD) is closely associated with metabolic
diseases, including obesity and diabetes, and has gradually become the most common …

Background The interaction between programmed death receptor (PD-1) and its ligand (PD-
L1) is essential for suppressing activated T-lymphocytes. However, the precise mechanisms …