Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-
associated macrophages (TAMs) enhance the aerobic glycolysis and apoptotic resistance of …

The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

For decades, lactate has been considered an innocuous bystander metabolite of cellular
metabolism. However, emerging studies show that lactate acts as a complex …

During tumorigenesis, breast tumour cells undergo metabolic reprogramming, which
generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and …

Tumor microenvironment (TME) consists of a dynamic network of non-tumoral stromal cells,
including cancer-associated fibroblasts, endothelial cells, tumor-associated macrophages …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …

Tumor heterogeneity is a hallmark of cancer and one of the primary causes of resistance to
therapies. Triple-negative breast cancer (TNBC), which accounts for 15–20% of all breast …

The anti-tumor activities of some members of the chemokine family are often overcome by
the functions of many chemokines that are strongly and causatively linked with increased …