Membrane proteins are a highly relevant class of biological molecules and comprise∼ 60%
of current drug targets. Before being analyzed by structural, biochemical, and biophysical …

Piezo ion channels are sensors of mechanical forces and mediate a wide range of
physiological mechanotransduction processes. More than a decade of intense research has …

Mechanosensitive (MS) ion channels are a ubiquitous type of molecular force sensor
sensing forces from the surrounding bilayer. The profound structural diversity in these …

Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and
shape cellular excitability. For the mechanosensitive subfamily of K2Ps, the composition of …

OSCA/TMEM63 channels, which have transporter-like architectures, are bona fide
mechanosensitive (MS) ion channels that sense high-threshold mechanical forces in …

The mechanosensitive channel of small conductance (MscS) protects bacteria against
hypoosmotic shock. It can sense the tension in the surrounding membrane and releases …

Inspired by mechanosensitive potassium channels found in nature, we developed a
fluorinated amphiphilic cyclophane composed of fluorinated rigid aromatic units connected …

OSCA/TMEM63 channels are the largest known family of mechanosensitive channels,–,
playing critical roles in plant,,–and mammalian, mechanotransduction. Here we determined …

In recent decades, the field of synthetic biology has witnessed remarkable progress, driving
advances in both research and practical applications. One pivotal area of development …

How can single cells without nervous systems perform complex behaviours such as
habituation, associative learning and decision making, which are considered the hallmark of …