Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful technology used to investigate the spatial distributions of thousands of molecules …

Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Low-molecular-weight (low-MW) compounds have many essential functions in biological
processes, and the molecular imaging of as many low-MW compounds as possible is critical …

Introduction: The development of precision medicine requires advanced technologies to
address the multifactorial disease stratification and to support personalized treatments …

The ability to target discrete features within tissue using liquid surface extractions enables
the identification of proteins while maintaining the spatial integrity of the sample. Here, we …

Cytochrome c oxidase subunit VIc (COX6c) is one of the most important subunits of the
terminal enzyme of the respiratory chain in mitochondria. Numerous studies have …

Due to its strong ultraviolet absorption, low background interference in the small molecular
range, and salt tolerance capacity, N-phenyl-2-naphthylamine (PNA) was developed as a …

Mitochondria, independent double-membrane organelles, are intracellular power plants that
feed most eukaryotic cells with the ATP produced via the oxidative phosphorylation …

Rationale Liquid extraction surface analysis (LESA) can be used to generate spatially
directed protein identifications in an imaging mass spectrometry (IMS) workflow. This …

Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) of
metabolites can reveal how metabolism is altered throughout heterogeneous tissues. Here …