Last-generation adenovirus vectors, also called helper-dependent or gutless adenovirus,
are very attractive for gene therapy because the associated in vivo immune response is …

It has become apparent that the clinical success anticipated in the field of gene therapy has
been limited by progress in several of the fundamental areas of genetics, molecular and …

Background: Mutations in low-density lipoprotein (LDL) receptor (LDLR) are one of the main
causes of familial hypercholesterolemia, which induces atherosclerosis and has a high …

Atherosclerosis is now recognized as an inflammatory disease involving the vascular wall.
Recent results indicate that acute inflammation does not simply passively resolve as …

Molecular mechanisms underlying the cold-associated high cardiovascular risk remain
unknown. Here, we show that the cold-triggered food-intake-independent lipolysis …

The innate immune response to intraportally infused adenoviral vector was evaluated in
rhesus monkeys. A first-generation adenovirus-expressing lacZ (Ad-lacZ) was administered …

Systemic intravascular delivery of adenoviral (Ad) vectors for liver-directed gene therapy has
been widely employed because of its simplicity, noninvasiveness, and potential for high …

The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein
(LDL) receptor family. In vitro and in vivo studies have shown that VLDL receptor binds …

Recent single-cell transcriptomes revealed spatiotemporal programmes of liver function on
the sublobular scale. However, how sexual dimorphism affected this space-time logic …

Background—Matrix metalloproteinase (MMP)–associated extracellular matrix degradation
is thought to contribute to the progression and rupture of atherosclerotic plaques. However …