Usually the dense extracellular structure in fibrotic tissues is described as extracellular
matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already …

Large, elastic arteries are composed of cells and a specialized extracellular matrix that
provides reversible elasticity and strength. Elastin is the matrix protein responsible for this …

Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Large artery stiffness, as measured by pulse wave velocity, is correlated with high blood
pressure and may be a causative factor in essential hypertension. The extracellular matrix …

Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core
surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as …

Conduit arteries become stiffer with age due to alterations in their morphology and the
composition of the their major structural proteins, elastin and collagen. The elastic lamellae …

Elastin is a key extracellular matrix protein that is critical to the elasticity and resilience of
many vertebrate tissues including large arteries, lung, ligament, tendon, skin, and elastic …

Biomaterials based upon elastin and elastin-derived molecules are increasingly
investigated for their application in tissue engineering. This interest is fuelled by the …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Extracellular elastic fibres provide mechanical elasticity to tissues and contribute towards the
processes of organ remodelling by affecting cell–cell signalling,. The formation of elastic …