To maintain genome stability, cells have evolved various DNA repair pathways to deal with
oxidative DNA damage. DNA damage response (DDR) pathways, including ATM-Chk2 and …

Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the
GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state …

Nuclear actin regulates transcriptional programmes in a manner dependent on its levels and
polymerisation state. This dynamics is determined by the balance of nucleocytoplasmic …

DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …

Genome integrity is critically dependent on timely DNA replication and accurate
chromosome segregation. Replication stress delays replication into G2/M, which in turn …

As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily
repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired …

The coordination of cell cycle progression with the repair of DNA damage supports the
genomic integrity of dividing cells. The function of many factors involved in DNA damage …

The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the
nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the …

In response to a variety of DNA replication stress or DNA damaging agents, the DNA
damage response (DDR) pathways are triggered for cells to coordinate DNA repair, cell …

APE2 plays important roles in the maintenance of genomic and epigenomic stability
including DNA repair and DNA damage response. Accumulating evidence has suggested …