A multi-component meningococcal serogroup B vaccine (4CMenB): the clinical development program

M O'Ryan, J Stoddard, D Toneatto, J Wassil, PM Dull - Drugs, 2014 - Springer
Recently approved in Europe and Australia, the multi-component meningococcal B vaccine,
4CMenB (Bexsero®, Novartis Vaccines and Diagnostics), contains three surface-exposed …

[HTML][HTML] MATS: Global coverage estimates for 4CMenB, a novel multicomponent meningococcal B vaccine

D Medini, M Stella, J Wassil - Vaccine, 2015 - Elsevier
Recently approved in the EU, US, Australia, and Canada, 4CMenB (Bexsero®, GSK
Vaccines) is a multi-component meningococcal B (MenB) vaccine containing 3 surface …

[HTML][HTML] Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain …

G Frosi, A Biolchi, ML Sapio, F Rigat, S Gilchrist… - Vaccine, 2013 - Elsevier
Abstract Background 4CMenB (Bexsero), a vaccine developed against invasive
meningococcal disease caused by capsular group B strains (MenB), was recently licensed …

[HTML][HTML] Genetic Meningococcal Antigen Typing System (gMATS): A genotyping tool that predicts 4CMenB strain coverage worldwide

A Muzzi, A Brozzi, L Serino, M Bodini, R Abad… - Vaccine, 2019 - Elsevier
Abstract Background The Meningococcal Antigen Typing System (MATS) was developed to
identify meningococcus group B strains with a high likelihood of being covered by the …

4CMenB journey to the 10-year anniversary and beyond

V Abitbol, F Martinón-Torres, MK Taha… - Human Vaccines & …, 2024 - Taylor & Francis
The 4-component meningococcal serogroup B (MenB) vaccine, 4CMenB, the first broadly
protective, protein-based MenB vaccine to be licensed, is now registered in more than 50 …

Emerging experience with meningococcal serogroup B protein vaccines

D Toneatto, M Pizza, V Masignani… - Expert review of …, 2017 - Taylor & Francis
Introduction: The successful development of two broadly protective vaccines targeting
Neisseria meningitidis serogroup B (MenB); 4CMenB and rLP2086, is the most significant …

Could the multicomponent meningococcal serogroup B vaccine (4CMenB) control Neisseria meningitidis capsular group X outbreaks in Africa?

E Hong, MM Giuliani, AE Deghmane, M Comanducci… - Vaccine, 2013 - Elsevier
A new vaccine, 4CMenB, is composed of surface proteins of Neisseria meningitidis and is
aimed to target serogroup B (MenB) isolates. The vaccine components are present in …

Immunogenicity of a meningococcal B vaccine during a university outbreak

NE Basta, AAF Mahmoud, J Wolfson… - … England Journal of …, 2016 - Mass Medical Soc
Background In December 2013, a multicomponent meningococcal serogroup B (4CMenB)
vaccine was used before licensure on the basis of special consideration by the Food and …

Meningococcal serogroup B strain coverage of the multicomponent 4CMenB vaccine with corresponding regional distribution and clinical characteristics in England …

SR Parikh, L Newbold, S Slater, M Stella… - The Lancet Infectious …, 2017 - thelancet.com
Summary Background The UK introduced 4CMenB—a multicomponent vaccine against
serogroup B meningococcal disease—into the national infant immunisation programme in …

[HTML][HTML] Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB)

JA Bettinger, DW Scheifele, SA Halperin, W Vaudry… - Vaccine, 2013 - Elsevier
Background In collaboration with the Canadian Immunization Monitoring Program Active
(IMPACT), the National Microbiology Laboratory, the UK Health Protection Agency and …