Hypertension affects approximately one third of the world's adult population and is a major
cause of premature death despite considerable advances in pharmacological treatments …

It is widely accepted that regular physical activity is beneficial for cardiovascular health.
Frequent exercise is robustly associated with a decrease in cardiovascular mortality as well …

Despite strong scientific evidence supporting the benefits of regular exercise for the
prevention and management of cardiovascular disease (CVD), physical inactivity is highly …

Obesity is a complex disease that affects whole body metabolism and is associated with an
increased risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D). Physical …

There is a pandemic of physical inactivity that appears to parallel the widespread
prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise …

On the 400th anniversary of Harvey's Lumleian lectures, this review focuses on
“hemodynamic” forces associated with the movement of blood through arteries in humans …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted as the document was compiled through …

In primary prevention, regular physical activity decreases the incidence of cardiovascular
disease. At the endothelial level, this decreased incidence was attributed to higher …