Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical
imaging, particularly for studying biological tissues deep within living organisms. MPFM …

The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Holistic understanding of physio-pathological processes requires noninvasive 3D imaging in
deep tissue across multiple spatial and temporal scales to link diverse transient subcellular …

Successful immune responses depend on the spatiotemporal coordination of immune cell
migration, interactions, and effector functions in lymphoid and parenchymal tissues. Real …

Intravital microscopy (IVM) expands our understanding of cellular and molecular processes,
with applications ranging from fundamental biology to (patho) physiology and immunology …

Lymph nodes (LNs) are organs of the immune system, critical for maintenance of
homeostasis and initiation of immune responses, yet there are few models that accurately …

Long-term observation of subcellular dynamics in living organisms is limited by background
fluorescence originating from tissue scattering or dense labeling. Existing confocal …

Cancer progression is significantly influenced by the complex interactions within the tumor
microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors …

Cancer immunotherapy has developed rapidly in recent years and stands as one of the most
promising techniques for combating cancer. To develop and optimize cancer …

Multiplex imaging has emerged as an invaluable tool for immune-oncologists and
translational researchers, enabling them to examine intricate interactions among immune …