Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents,
postoperative cognitive decline (POCD) is associated with the inflammatory activation of …

Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins,
are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty …

Microglia are rapidly activated after acute ischemic stroke, and the polarization of microglial
is associated with the prognosis of acute ischemic stroke. Lipoxin A4 (LXA4), an anti …

The hyperactive state of sensory neurons in the spinal cord enhances pain transmission.
Spinal glial cells have also been implicated in enhanced excitability of spinal dorsal horn …

Formyl peptide receptors (FPRs) comprise a class of chemoattractant pattern recognition
receptors, for which several physiological functions like host-defences, as well as the …

Abstract Maresin-2 (MaR2) is a specialized pro-resolution lipid mediator (SPM) that reduces
neutrophil recruitment in zymosan peritonitis. Here, we investigated the analgesic effect of …