[HTML][HTML] Animal models of drug-induced liver injury

MR McGill, H Jaeschke - Biochimica et Biophysica Acta (BBA)-Molecular …, 2019 - Elsevier
Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and
regulators. It is the most common cause of acute liver failure in the US. It is also one of the …

The role of apoptosis in acetaminophen hepatotoxicity

H Jaeschke, L Duan, JY Akakpo, A Farhood… - Food and chemical …, 2018 - Elsevier
Although necrosis is recognized as the main mode of cell death induced by acetaminophen
(APAP) overdose in animals and humans, more recently an increasing number of …

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

MR McGill, CD Williams, Y Xie… - Toxicology and applied …, 2012 - Elsevier
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
West. In mice, APAP hepatotoxicity can be rapidly induced with a single dose. Because it is …

[HTML][HTML] Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats

A Abirami, G Nagarani, P Siddhuraju - Food science and human wellness, 2015 - Elsevier
The present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix
and Citrus maxima (Red and White variety) methanolic leaf extracts on paracetamol induced …

[HTML][HTML] Clinical outcomes of occupational exposure to n, n-dimethylformamide: perspectives from experimental toxicology

TH Kim, SG Kim - Safety and health at work, 2011 - Elsevier
N, N-Dimethylformamide (DMF) is globally used as an organic solvent in the production of
synthetic leather and resins because of its low volatility, making it an attractive industrial …

The deleterious effects of N, N-dimethylformamide on liver: A mini-review

MJ Li, T Zeng - Chemico-biological interactions, 2019 - Elsevier
Abstract N, N-dimethylformamide (DMF) is a versatile solvent with wide industrial
applications. Evidences from animal studies and occupational poisoning cases have clearly …

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

L Hussain, J Ikram, K Rehman, M Tariq… - Turkish Journal of …, 2014 - journals.tubitak.gov.tr
Malva sylvestris is traditionally used for the treatment of liver diseases, but sufficient
pharmacological-based scientific literature is not available online to authenticate its use in …

Biological actions of drug solvents

T Kelava, I Ćavar, F Čulo - Periodicum biologorum, 2011 - hrcak.srce.hr
Sažetak Many biologic agents are weakly soluble in water. Therefore, they should be
dissolved in organic lipophilic solvents (vehicles). A drug vehicle is a substance of no …

[HTML][HTML] Epiphytic Acampe ochracea orchid relieves paracetamol-induced hepatotoxicity by inhibiting oxidative stress and upregulating antioxidant genes in in vivo …

AMA Ahmed, MA Rahman, MA Hossen… - Biomedicine & …, 2021 - Elsevier
Orchids are basically ornamental, and biological functions are seldom evaluated. This
research investigated the effects of Acampe ochracea methanol extract (AOME) in …

[HTML][HTML] Acetaminophen-induced apoptosis: Facts versus fiction

H Jaeschke, A Ramachandran - Journal of Clinical and …, 2020 - ncbi.nlm.nih.gov
An overdose of the widely used analgesic acetaminophen (APAP) is the most common
cause of acute liver failure in the western world and hence is a clinically significant problem …