Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …

Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

A targeted and logical discovery method was devised for natural products containing
piperazic acid (Piz), which is biosynthesized from ornithine by l-ornithine N-hydroxylase …

Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …

Molecules containing a nitrogen–nitrogen (N–N) linkage have a variety of structures and
biological activities; however, no enzyme has yet been demonstrated to catalyze N–N bond …

Piperazic acid (Piz) is a nonproteinogenic amino acid possessing a rare nitrogen–nitrogen
bond. However, little is known about how Piz is incorporated into nonribosomal peptides …

Covering: up through August 2011 This review covers the emerging biosynthetic role of
crotonyl-CoA carboxylase/reductase (CCR) homologs in extending the structural and …

Recent studies described several different routes that facilitate nitrogen–nitrogen bond
formation in natural product biosynthesis. We report herein the identification of …

Covering: up to the end of 2018 Piperazic acid is a cyclic hydrazine and a non-proteinogenic
amino acid found in diverse non-ribosomal peptide (NRP) and hybrid NRP–polyketide (PK) …