Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

M Merad, F Ginhoux, M Collin - Nature Reviews Immunology, 2008 - nature.com
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the
epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in …

Langerhans cells and more: langerin‐expressing dendritic cell subsets in the skin

N Romani, BE Clausen, P Stoitzner - Immunological reviews, 2010 - Wiley Online Library
Langerhans cells (LCs) are antigen‐presenting dendritic cells (DCs) that reside in epithelia.
The best studied example is the LC of the epidermis. By electron microscopy, their …

Type I IFNs enhance the terminal differentiation of dendritic cells

T Luft, KC Pang, E Thomas, P Hertzog… - The Journal of …, 1998 - journals.aai.org
This study identifies type I IFNs as activating cytokines in a serum-free system in which
human dendritic cells (DC) were generated from CD34+ progenitor cells. After 14 days of …

Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.

U O'doherty, M Peng, S Gezelter, WJ Swiggard… - …, 1994 - ncbi.nlm.nih.gov
Two subsets of dendritic cells, differing in T-cell stimulatory function, have been purified
directly from human blood. Both subsets are positive for major histocompatibility complex …

Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

A Tang, M Amagai, LG Granger, JR Stanley, MC Uddy - Nature, 1993 - nature.com
LANGERHANS cells (LC) are the principal accessory cells present in epidermis1. Because
LC have limited capacity for self-renewal2, epidermis is continually repopulated by as-yet …

Ontogeny and functional specialization of dendritic cells in human and mouse

M Haniffa, M Collin, F Ginhoux - Advances in immunology, 2013 - Elsevier
Dendritic cells (DCs) are a heterogeneous group of functionally specialized antigen-
presenting cells that initiate and orchestrate immune responses. Our understanding of DC …

Langerhans cells–dendritic cells of the epidermis

N Romani, S Holzmann, CH Tripp, F Koch, P Stoitzner - Apmis, 2003 - Wiley Online Library
Langerhans cells – dendritic cells of the epidermis - ROMANI - 2003 - APMIS - Wiley Online
Library Skip to Article Content Skip to Article Information Wiley Online Library Wiley Online …

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

M Merad, P Hoffmann, E Ranheim, S Slaymaker… - Nature medicine, 2004 - nature.com
Skin is the most commonly affected organ in graft-versus-host disease (GVHD). To explore
the role of Langerhans cells in GVHD, the principal dendritic cells of the skin, we studied the …

Pathogenesis of Langerhans cell histiocytosis

G Badalian-Very, JA Vergilio, M Fleming… - Annual Review of …, 2013 - annualreviews.org
Langerhans cell histiocytosis (LCH) combines in one nosological category a group of
diseases that have widely disparate clinical manifestations but are all characterized by …

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.

CA Elmets, PR Bergstresser, RE Tigelaar… - The Journal of …, 1983 - rupress.org
Acute, low dose ultraviolet B radiation of murine body wall skin followed by local application
of DNFB produces a state of antigen-specific unresponsiveness. This state is maintained at …