Abstract Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that
prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL …

Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-
family interactions makes it challenging to predict cell fate via standard molecular biology …

Mcl-1 is a member of the Bcl-2 family of proteins that promotes cell survival by preventing
induction of apoptosis in many cancers. High expression of Mcl-1 causes tumorigenesis and …

The MCL1 gene is frequently amplified in cancer and codes for the antiapoptotic protein
myeloid cell leukemia 1 (MCL1), which confers resistance to the current standard of care …

Hepatocellular death is present in almost all types of human liver disease and is used as a
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Angiogenesis and signaling through the RAF/mitogen-activated protein/extracellular signal-
regulated kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important …

Abstract MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of
multiple cell lineages, is also among the most highly amplified genes in cancer. Although …

Cancer is a daunting global problem confronting the world's population. The most frequent
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …

Based on microarray data, we have previously shown a significant down‐regulation of miR‐
29 in hepatocellular carcinoma (HCC) tissues. To date, the role of miR‐29 deregulation in …