Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor
dysfunction. Aging is the greatest risk factor for developing PD. Recent molecular genetic …

Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy
bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as …

Objectives To explore the genetic architecture of PD in the Luxembourg Parkinson's Study
including cohorts of healthy people and patients with Parkinson's disease (PD) and atypical …

To investigate the prevalence and genotype-phenotype correlations of parkin RBR E3
ubiquitin protein ligase (PRKN) variants in Parkinson's disease (PD), we first included 2,527 …

Missense variants in leucine-rich repeat kinase 2 (LRRK2) lead to familial and sporadic
Parkinson's disease (PD). The pathological features of PD patients with LRRK2 variants …

Loss of either PINK1 or PRKN causes an early onset Parkinson's disease (PD) phenotype.
Functionally, PINK1 and PRKN work together to mediate stress-activated mitochondrial …

Introduction: There has been a bias in the existing literature on Parkinson's disease (PD)
genetics as most studies involved patients of European ancestry, mostly in Europe and …

Parkin, the gene responsible for hereditary Parkinson's disease (PD) called “Autosomal
Recessive Juvenile Parkinsonism (AR-JP)” was discovered a quarter of a century ago …

Parkinson's disease (PD) rodent models provide insight into the relationship between
nigrostriatal dopamine (DA) signaling and locomotor function. Although toxin-based rat …

Introduction Although genetic factors are known to play a role in the pathogenesis of
Parkinson's disease (PD), true prevalence of familial PD is unknown. We conducted this pilot …