Understanding the interaction of polyelectrolyte architectures with proteins and biosystems

K Achazi, R Haag, M Ballauff… - Angewandte Chemie …, 2021 - Wiley Online Library
The counterions neutralizing the charges on polyelectrolytes such as DNA or heparin may
dissociate in water and greatly influence the interaction of such polyelectrolytes with …

Thermodynamic analysis of the interaction of heparin with lysozyme

JJ Walkowiak, M Ballauff, R Zimmermann… - …, 2020 - ACS Publications
Glycosaminoglycan (GAG)–protein binding governs critically important signaling events in
living matter. Aiming at a quantitative analysis of the involved processes, we herein present …

Exploring structure–property relationships of GAGs to tailor ECM-mimicking hydrogels

R Zimmermann, C Werner, J Sterling - Polymers, 2018 - mdpi.com
Glycosaminoglycans (GAGs) are a class of linear polysaccharides that are ubiquitous in the
extracellular matrix (ECM) and on cell surfaces. Due to their key role in development …

Electrostatic forces as dominant interactions between proteins and polyanions: an ESI MS study of fibroblast growth factor binding to heparin oligomers

BB Minsky, PL Dubin, IA Kaltashov - Journal of The American …, 2017 - ACS Publications
The interactions between fibroblast growth factors (FGFs) and their receptors (FGFRs) are
facilitated by heparan sulfate (HS) and heparin (Hp), highly sulfated biological …

Critical influence of cosolutes and surfaces on the assembly of serpin-derived amyloid fibrils

MW Risør, DW Juhl, M Bjerring, J Mathiesen… - Biophysical journal, 2017 - cell.com
Many proteins and peptides self-associate into highly ordered and structurally similar
amyloid cross-β aggregates. This fibrillation is critically dependent on properties of the …

Influence of Nε-Protecting Groups on the Protease-Catalyzed Oligomerization of l-Lysine Methyl Ester

X Qin, W Xie, S Tian, MA Ali, A Shirke, RA Gross - ACS Catalysis, 2014 - ACS Publications
The direct oligomerization of l-lys-OMe by bromelain catalysis gave oligo (l-lys) with
DPavg∼ 3.6 and dispersity∼ 1.1. Since higher chain length oligo (l-lys) with lower …

Molecular dynamics simulations illuminate the role of counterion condensation in the electrophoretic transport of homogalacturonans

AH Irani, JL Owen, D Mercadante… - …, 2017 - ACS Publications
Homogalacturonans (HGs) are polysaccharide copolymers of galacturonic acid and its
methylesterified counterpart. The inter-and intramolecular distributions of the methylesterifed …

Mode of heparin attachment to nanocrystalline hydroxyapatite affects its interaction with bone morphogenetic protein-2

CS Goonasekera, KS Jack, G Bhakta, B Rai… - …, 2015 - pubs.aip.org
Heparin has a high affinity for bone morphogenetic protein-2 (BMP-2), which is a key growth
factor in bone regeneration. The aim of this study was to investigate how the rate of release …

Wechselwirkung von Polyelektrolyt‐Architekturen mit Proteinen und Biosystemen

K Achazi, R Haag, M Ballauff, J Dernedde… - Angewandte …, 2021 - Wiley Online Library
Gegenionen, die die Ladungen von Polyelektrolyten wie DNA oder Heparin neutralisieren,
können im Wasser dissoziieren und beeinflussen stark deren Wechselwirkung mit …

Charged polysaccharides as model polyelectrolytes: computational studies of transport and conformational properties: a thesis presented in partial fulfilment of the …

AH Irani - 2018 - mro.massey.ac.nz
Homogalacturonans (HGs) are polysaccharide co-polymers of galacturonic acid and its
methylesterified counterpart, that play a crucial role in the mechanobiology of the cell walls …