Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
WJ Valentine, K Yanagida, H Kawana, N Kono… - Journal of Biological …, 2022 - ASBMB
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis
Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis
LPCAT3 is an integral membrane acyltransferase in the Lands cycle responsible for
generating C20: 4 phospholipids and has been implicated in key biological processes such …
generating C20: 4 phospholipids and has been implicated in key biological processes such …
Mechanisms and inhibition of Porcupine-mediated Wnt acylation
Wnt signalling is essential for regulation of embryonic development and adult tissue
homeostasis,–, and aberrant Wnt signalling is frequently associated with cancers. Wnt …
homeostasis,–, and aberrant Wnt signalling is frequently associated with cancers. Wnt …
The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3
Q Zhang, D Yao, B Rao, L Jian, Y Chen, K Hu… - Nature …, 2021 - nature.com
As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de
novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation …
novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation …
Lipodistrophy: a paradigm for understanding the consequences of “overloading” adipose tissue
K Lim, A Haider, C Adams, A Sleigh… - Physiological …, 2021 - journals.physiology.org
Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …
their rarity, tended to attract considerable medical attention because of the severity and …
The uniqueness of clear cell renal cell carcinoma: summary of the process and abnormality of glucose metabolism and lipid metabolism in ccRCC
X Qi, Q Li, X Che, Q Wang, G Wu - Frontiers in Oncology, 2021 - frontiersin.org
Kidney cancer is a cancer with an increasing incidence in recent years. Clear cell renal cell
carcinoma (ccRCC) accounts for up to 80% of all kidney cancers. The understanding of the …
carcinoma (ccRCC) accounts for up to 80% of all kidney cancers. The understanding of the …
Non-contaminating cryogenic fluid access to high-temperature resources: Liquid nitrogen fracturing in a lab-scale Enhanced Geothermal System
Hot dry rock (HDR) geothermal energy exploitation is essential to meet the energy demand
and achieve low-carbon solutions. Creation of complex fracture networks in HDR by …
and achieve low-carbon solutions. Creation of complex fracture networks in HDR by …
Lipid metabolism in glioblastoma: from de novo synthesis to storage
Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options,
novel therapies are desperately needed. Recent studies have shown that GBM acquires …
novel therapies are desperately needed. Recent studies have shown that GBM acquires …