The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …

In this review we present critical overview of some of the available literature on the
fundamental biology of telomeres and telomerase in Metazoan. With the exception of …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

Tandem DNA repeats derived from the ancestral (TTAGGG) n run were first detected at
chromosome ends of the majority of living organisms, hence the name telomeric DNA …

In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes
consecutive guanines and may hence fold into G-quadruplexes. Budding yeasts have …

Trypanosoma brucei expresses variant surface glycoprotein (VSG) genes in a strictly
monoallelic fashion in its mammalian hosts, but it is unclear how this important virulence …

Highly concentrated radionuclide waste produced during the Cold War era is stored at US
Department of Energy (DOE) production sites. This radioactive waste was often highly acidic …

In budding yeast, Cdc13, Stn1, and Ten1 form a heterotrimeric complex (CST) that is
essential for telomere protection and maintenance. Previous bioinformatics analysis …

Alteration of the epigenome is associated with a wide range of human diseases. Therefore,
deciphering the pathways that regulate the epigenetic modulation of gene expression is a …

Telomeres, ubiquitous and essential structures of eukaryotic chromosomes, are known to
come in a variety of forms, but knowledge about their actual diversity and evolution across …