[HTML][HTML] Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway
J Barry, MTN Bui, MS Levine, C Cepeda - Neurobiology of disease, 2022 - Elsevier
Huntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a
mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and …
mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and …
Translation of microRNA-based huntingtin-lowering therapies from preclinical studies to the clinic
J Miniarikova, MM Evers, P Konstantinova - Molecular Therapy, 2018 - cell.com
The single mutation underlying the fatal neuropathology of Huntington's disease (HD) is a
CAG triplet expansion in exon 1 of the huntingtin (HTT) gene, given rise to a toxic mutant …
CAG triplet expansion in exon 1 of the huntingtin (HTT) gene, given rise to a toxic mutant …
Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice
Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs),
whereby a widely expressed protein causes lesions in specific cell types and brain regions …
whereby a widely expressed protein causes lesions in specific cell types and brain regions …
[HTML][HTML] Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease
S Vas, AU Nicol, L Kalmar, J Miles, AJ Morton - Neurobiology of disease, 2021 - Elsevier
Sleep disruption is a common invisible symptom of neurological dysfunction in Huntington's
disease (HD) that takes an insidious toll on well-being of patients. Here we used …
disease (HD) that takes an insidious toll on well-being of patients. Here we used …
Changes in brain activity with tominersen in early-manifest Huntington's disease
It is unknown whether alterations in EEG brain activity caused by Huntington's disease may
be responsive to huntingtin-lowering treatment. We analysed EEG recordings of 46 patients …
be responsive to huntingtin-lowering treatment. We analysed EEG recordings of 46 patients …
Neurophysiological hallmarks of Huntington's disease progression: an EEG and fMRI connectivity study
NV Ponomareva, SA Klyushnikov… - Frontiers in Aging …, 2023 - frontiersin.org
Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) can
provide corroborative data on neurophysiological alterations in Huntington's disease (HD) …
provide corroborative data on neurophysiological alterations in Huntington's disease (HD) …
Sex differences in sleep architecture in a mouse model of Huntington's disease
Sleep and circadian rhythm disturbances are common features of Huntington's disease
(HD). HD is an autosomal dominant neurodegenerative disorder that affects men and …
(HD). HD is an autosomal dominant neurodegenerative disorder that affects men and …
Quantitative EEG analysis in Angelman syndrome: candidate method for assessing therapeutics
The goal of these studies was to use quantitative (q) EEG techniques on data from children
with Angelman syndrome (AS) using spectral power analysis, and to evaluate this as a …
with Angelman syndrome (AS) using spectral power analysis, and to evaluate this as a …
Circadian dysfunction in the Q175 model of Huntington's disease: Network analysis
Disturbances in sleep/wake cycle are a common complaint of individuals with Huntington's
disease (HD) and are displayed by HD mouse models. The underlying mechanisms …
disease (HD) and are displayed by HD mouse models. The underlying mechanisms …
[HTML][HTML] Neurophysiological correlates of non-motor symptoms in late premanifest and early-stage manifest Huntington's disease
Objective To find sensitive neurophysiological correlates of non-motor symptoms in
Huntington's disease (HD), which are essential for the development and assessment of …
Huntington's disease (HD), which are essential for the development and assessment of …