The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

PPARγ as a therapeutic target in diabetic nephropathy and ot... : Current Opinion in Nephrology
and Hypertension PPARγ as a therapeutic target in diabetic nephropathy and other renal …

Recent research has revealed roles for the peroxisome proliferator activated receptor
(PPAR) family of transcription factors in blood pressure regulation, expanding the possible …

Renin is the key regulated step in the enzymatic cascade that leads to angiotensin
generation and the control of blood pressure and fluid/electrolyte homeostasis. In the adult …

Involvement of the nuclear receptor peroxisome proliferator‐activated receptor gamma
(PPARγ) in kidney physiology has been explored recently. Synthetic PPARγ ligands can …

This review on intra‐individual factors affecting drug metabolism completes our series on the
biochemistry of drug metabolism. The article presents the molecular mechanisms causing …

Many transcription factors (TFs) have the ability to cooperate on DNA elements as
heterodimers. Despite the significance of TF heterodimerization for gene regulation, a …

Simple Summary This study investigates the combined therapeutic potential of revumenib
and tamibarotene in acute myeloid leukemia (AML) with histone-lysine-N-methyltransferase …

The renin phenotype: roles and regulation in the kidney : Current Opinion in Nephrology and
Hypertension The renin phenotype: roles and regulation in the kidney : Current Opinion in …