Linkage disequilibrium—the nonrandom association of alleles at different loci—is a sensitive
indicator of the population genetic forces that structure a genome. Because of the explosive …

Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation,
distinguished from rare variations by a requirement for the least abundant allele to have a …

Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

Hereditary haemochromatosis (HH), which affects some 1 in 400 and has an estimated
carrier frequency of 1 in 10 individuals of Northern European descent, results in multi–organ …

Congenital nephrotic syndrome of the Finnish type (NPHS1) is an autosomal-recessive
disorder, characterized by massive proteinuria in utero and nephrosis at birth. In this study …

Medical genetics was revolutionized during the 1980s by the application of genetic mapping
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …

▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These
complex polysaccharides provide docking sites for numerous protein ligands and receptors …

Statistical Genomics: Linkage, Mapping, and QTL Analysis Page 1 Page 2 Statistical Genomics
Linkage, Mapping, and QTL Analysis CRCPress Ben Hui Liu Boca Raton London New York …

In most human populations, the ability to digest lactose contained in milk usually disappears
in childhood, but in European-derived populations, lactase activity frequently persists into …