MYC, a major oncogenic transcription factor, regulates target genes involved in various
pathways such as cell proliferation, metabolism and immune evasion, playing a critical role …

Can Vaccines Stop Cancer Before It Starts? Assessing the Promise of Prophylactic
Immunization Against High-Risk Preneoplastic Lesions Loading logo Journals Policies …

Hepatoblastoma (HB) is an uncommon malignant liver cancer primarily affecting infants and
children, characterized by the presence of tissue that resembling fetal hepatocytes, mature …

The γ-glutamyl transpeptidase (γ-GGT) is an important tumor marker, which has been
reported to be firmly associated with the developmental stage of liver cancer. Therefore, it …

Abstract c-MYC is an important driver of high-risk neuroblastoma. A lack of c-MYC–driven
genetically engineered mouse models (GEMM) has hampered the ability to better …

In the growth and development of multicellular organisms, the immune processes of the
immune system and the maintenance of the organism's internal environment, cell …

Spatial transcriptomics, leveraging sequencing-and imaging-based techniques, has
emerged as a groundbreaking technology for mapping gene expression within the complex …

Background: Hepatoblastoma, the most common pediatric liver malignancy, is characterized
by significant molecular heterogeneity and poor prognosis in advanced stages. Recent …

In the field of digestive system tumor research, spatial transcriptomics technologies are used
to delve into the spatial structure and the spatial heterogeneity of tumors and to analyze the …

Hepatoblastoma stands as the most prevalent liver cancer in the pediatric population.
Characterized by a low mutational burden, chromosomal and epigenetic alterations are key …