Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of
plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Recent studies have revealed the genetic aberrations involved in the initiation and
progression of various cancers, including multiple myeloma (MM), via next-generation …

Purpose: Copy-number changes and translocations have been studied extensively in many
datasets with long-term follow-up. The impact of mutations remains debated given the short …

Over the last decade, sequencing of primary tumors has clarified the genetic underpinnings
of Wilms tumor but has not affected therapy, outcome, or toxicity. We now sharpen our focus …

As germline predisposition to hematopoietic malignancies has gained increased recognition
and attention in the field of oncology, it is important for clinicians to use a systematic …

Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling
intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory …

Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological
family studies going back to the 1920s have provided evidence for familial aggregation …

With the advent of precision genomics, hereditary predisposition to hematopoietic
neoplasms—collectively known as hereditary predisposition syndromes (HPS)—are being …

Inherited predisposition to haematopoietic malignancies, due to deleterious germline
variants in a variety of genes, is an important clinical entity with implications for the health …