The histone acetyltransferase Gcn5 is conserved throughout eukaryotes where it functions
as part of large multi-subunit transcriptional coactivator complexes that stimulate gene …

The general transcription factor TBP (TATA-box binding protein) and its associated factors
(TAFs) together form the TFIID complex, which directs transcription initiation. Through RNAi …

During Drosophila oogenesis, follicle cells sequentially undergo three distinct cell-cycle
programs: the mitotic cycle, endocycle and gene amplification. Notch signaling plays a …

Components of the SWI/SNF chromatin-remodeling complex are among the most frequently
mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the …

Metazoan development requires coordination of signaling pathways to regulate patterns of
gene expression. In Drosophila, the wing imaginal disc provides an excellent model for the …

The transcriptional mechanisms that allow neural stem cells (NSC) to balance self-renewal
with differentiation are not well understood. Employing an in vivo RNAi screen we identify …

Notch signaling pathway plays crucial roles in animal development. Protein ubiquitination
contributes to Notch signaling regulation by governing the stability and activity of major …

Background: Two big issues in the study of pathogens are determining how pathogens infect
hosts and how the host defends itself against infection. Therefore, investigating host …

Fatty acid β-oxidation is an essential pathogenic mechanism in nonalcoholic fatty liver
disease (NAFLD), and TATA-box binding protein associated factor 9 (TAF9) has been …

The histone acetyltransferase (HAT) Gcn5 was first characterized in yeast, and is conserved
throughout eukaryotes where it functions as part of large multi-subunit transcriptional …