Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the
pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in …

Direct compaction (DC) is considered to be the most effective method of tablet production.
However, only a small number of the active pharmaceutical ingredients (APIs) can be …

Multi-unit pellet system (MUPS) tablets were fabricated by compacting drug-loaded pellets of
either crospovidone or microcrystalline cellulose core. These pellets were produced by …

Helium pycnometry, a commonly used technique for measuring the true density of powders,
is sensitive to the release of volatiles during measurement. This can lead to over-estimated …

Compaction of sustained release coated pellets into multi-unit pellet system (MUPS) tablets
has been associated with damage to the functional polymer layer, leading to a loss in …

Multiple-unit dosage forms prepared by compacting pellets offer important manufacturing
and compliance advantages over pellet-filled capsules. However, compaction may …

Diffusion-limited, heterogeneously-catalysed processes mean choices influencing pore
structure-transport relationships, made during pellet fabrication, affect product performance …

The influences of the punch face design on multi-unit pellet system (MUPS) tablets were
investigated. Drug-loaded pellets coated with sustained release polymer based on …

Ce travail de thèse s' est intéressé à développer une nouvelle approche de caractérisation
du comportement mécanique des milieux particulaires, à travers l'analyse d'image obtenue …