Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2 DM) are highly prevalent aging‐
related diseases associated with significant morbidity and mortality. Some findings in human …
related diseases associated with significant morbidity and mortality. Some findings in human …
Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction
L Ungar, A Altmann, MD Greicius - Brain imaging and behavior, 2014 - Springer
Alzheimer's disease (AD) is an increasingly prevalent, fatal neurodegenerative disease that
has proven resistant, thus far, to all attempts to prevent it, forestall it, or slow its progression …
has proven resistant, thus far, to all attempts to prevent it, forestall it, or slow its progression …
[HTML][HTML] APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
Background The APOE effect on Alzheimer Disease (AD) risk is stronger in women than in
men but its mechanisms have not been established. We assessed the APOE-by-sex …
men but its mechanisms have not been established. We assessed the APOE-by-sex …
Imaging brain effects of APOE4 in cognitively normal individuals across the lifespan
The ε4 allele of the apolipoprotein E (APOE4) is associated with an increased risk of
developing Alzheimer's disease (AD). Hence, several studies have compared the brain …
developing Alzheimer's disease (AD). Hence, several studies have compared the brain …
Sex differences in the association between apolipoprotein E ε4 allele and Alzheimer's disease markers
Introduction We determined whether the effect of apolipoprotein E (APOE)-ε4 genotype on
Alzheimer's disease (AD) markers differs in men and women across AD stages. Methods …
Alzheimer's disease (AD) markers differs in men and women across AD stages. Methods …
Relative effect of APOE ε4 on neuroimaging biomarker changes across the lifespan
J Gonneaud, EM Arenaza-Urquijo, M Fouquet… - Neurology, 2016 - AAN Enterprises
Objective: To provide a comprehensive understanding of APOE ε4 effects across the
lifespan on the 3 main neuroimaging biomarkers. Methods: Two hundred seven community …
lifespan on the 3 main neuroimaging biomarkers. Methods: Two hundred seven community …
Regional patterns of gray matter volume, hypometabolism, and beta-amyloid in groups at risk of Alzheimer's disease
Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) deposition and
neurodegeneration. To seek for signs of such pathologies, we compared regional biomarker …
neurodegeneration. To seek for signs of such pathologies, we compared regional biomarker …
Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice
Human ApoE4 accelerates memory decline in ageing and in Alzheimer's disease. Although
intranasal insulin can improve cognition, this has little effect in ApoE4 subjects. To …
intranasal insulin can improve cognition, this has little effect in ApoE4 subjects. To …
Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults
AM DiBattista, BW Stevens, GW Rebeck… - Frontiers in human …, 2014 - frontiersin.org
Alzheimer's disease (AD) risk genes alter brain structure and function decades before
disease onset. Apolipoprotein E (APOE) is the strongest known genetic risk factor for AD …
disease onset. Apolipoprotein E (APOE) is the strongest known genetic risk factor for AD …
Effect of APOE ε4 genotype on amyloid‐β, glucose metabolism, and gray matter volume in cognitively normal individuals and amnestic mild cognitive impairment
W Li, R Li, S Yan, Z Zhao, Y Shan, Z Qi… - European Journal of …, 2023 - Wiley Online Library
Background and purpose The presence of apolipoprotein E ε 4 (APOE ε 4) is associated
with an increased risk of developing Alzheimer disease (AD). The aim of this study was to …
with an increased risk of developing Alzheimer disease (AD). The aim of this study was to …