Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

The aggregation by antigen of the IgE bound to its high affinity receptor on mast cells
initiates a complex series of biochemical events that result in the release of inflammatory …

Background Allergic conjunctivitis (AC) resulting from conjunctival reactive inflammation is a
common ocular surface disease. Quercetin is known for its anti-allergic properties but its …

Syk is an essential non-receptor tyrosine kinase in intracellular immunological signaling,
and the control of Syk kinase function is considered as a valuable target for pharmacological …

Allergic and autoimmune disorders share significant functional overlap in the biologic
pathways responsible for the activation of signal transduction events leading to production of …

B-cell receptor (BCR) signaling is essential for normal B-cell development, selection,
survival, proliferation, and differentiation into antibody-secreting cells. Similarly, this pathway …

Background The recognition of pathogen patterns followed by the production of reactive
oxygen species (ROS) during the oxidative burst is one of the major functions of …

The protein tyrosine kinase Syk plays a critical role in FcεRI signaling in mast cells. Binding
of Syk to phosphorylated immunoreceptor tyrosine‐based activation motifs (p‐ITAM) of the …

Mast cell tumors are a large group of diseases occurring in dogs, cats, mice, as well as in
humans. Systemic mastocytosis (SM) is a disease involving the accumulation of mast cells in …

To elucidate the function of type II ice structuring protein (ISP II) in the cold tolerance and
resistance of Ruditapes philippinarum, we investigated ISP II mRNA expression, the …