Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions

A Zarkali, GEC Thomas, H Zetterberg… - Nature …, 2024 - nature.com
A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …

Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling

F Loreto, S Verdi, SM Kia, A Duvnjak… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to
diagnostic delays and failures. Neuroanatomical normative modeling captures individual …

Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis

R Cirstian, N Forde, G Zhang, GS Hellemann… - bioRxiv, 2024 - biorxiv.org
This study presents large-scale normative models of white matter (WM) organization across
the lifespan, using diffusion MRI data from over 25,000 healthy individuals aged 0-100 …