Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions
Kidney-targeted nanoparticles have become of recent interest due to their potential to
deliver drugs directly to diseased tissue, decrease off-target adverse effects, and increase …
deliver drugs directly to diseased tissue, decrease off-target adverse effects, and increase …
Risk–efficacy balance of ulipristal acetate compared to surgical alternatives
MA Middelkoop, PM Bet, JPH Drenth… - British journal of …, 2021 - Wiley Online Library
Aims Uterine fibroids are benign tumours that cause various complaints. These complaints
may significantly compromise quality of life, necessitating a clinical intervention in 25–50 …
may significantly compromise quality of life, necessitating a clinical intervention in 25–50 …
The effect of size, charge, and peptide ligand length on kidney targeting by small, organic nanoparticles
Chronic kidney disease (CKD) affects 15% of the US adult population. However, most
clinically available drugs for CKD show low bioavailability to the kidneys and non‐specific …
clinically available drugs for CKD show low bioavailability to the kidneys and non‐specific …
Investigation of basolateral targeting micelles for drug delivery applications in polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is a complex disorder
characterized by uncontrolled renal cyst growth, leading to kidney function decline. The …
characterized by uncontrolled renal cyst growth, leading to kidney function decline. The …
Combining metformin and drug-loaded kidney-targeting micelles for polycystic kidney disease
Introduction Autosomal dominant polycystic kidney disease (ADPKD) is the most common
inherited kidney disease that leads to eventual renal failure. Metformin (MET), an AMP …
inherited kidney disease that leads to eventual renal failure. Metformin (MET), an AMP …
Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities
S Hammond, X Meng, J Barber… - Toxicological …, 2025 - academic.oup.com
Tolvaptan is a vasopressin V2 receptor antagonist which has proven to be an effective and
mostly well-tolerated agent for the treatment of autosomal-dominant polycystic kidney …
mostly well-tolerated agent for the treatment of autosomal-dominant polycystic kidney …
ECloudGen: Leveraging Electron Clouds as a Latent Variable to Scale Up Structure-based Molecular Design
Abstract Structure-based molecule generation represents a significant advancement in AI-
aided drug design (AIDD). However, progress in this domain is constrained by the scarcity of …
aided drug design (AIDD). However, progress in this domain is constrained by the scarcity of …
Oral delivery of nanomedicine for genetic kidney disease
Y Huang, J Wang, V Mancino, J Pham, C O'Grady… - PNAS …, 2024 - academic.oup.com
Chronic and genetic kidney diseases such as autosomal dominant polycystic kidney
disease (ADPKD) have few therapeutic options, and clinical trials testing small molecule …
disease (ADPKD) have few therapeutic options, and clinical trials testing small molecule …
Oral delivery of kidney targeting nanotherapeutics for polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal
disorder. Although a variety of candidate drugs have been found to modulate cystogenesis …
disorder. Although a variety of candidate drugs have been found to modulate cystogenesis …
Palatability of two different formulations of urea for the treatment of hyponatremia: A double-blind, randomized, cross-over study
Background and aims Hyponatremia (HN) is the most common disorder of electrolytes
encountered in clinical practice. Considering that HN is associated with high morbidity and …
encountered in clinical practice. Considering that HN is associated with high morbidity and …