Abstract Purpose of the Review Osteoarthritis (OA) is an aging-associated and injury-
induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent …

It is well known that adipokines are endocrine factors that are mainly secreted by white
adipose tissue. Their central role in energy metabolism is currently accepted. More recently …

The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

Adiposity is central to aging and several chronic diseases. Adiposity encompasses not just
the excess adipose tissue but also body fat redistribution, fat infiltration, hypertrophy of …

The growing burden of obesity and osteoporosis is a major public health concern. Emerging
evidence of the role of adipokines on bone metabolism has led to the discovery of novel …

As a multifaceted adipokine, chemerin has been found to perform functions vital for
immunity, adiposity, and metabolism through its three known receptors (chemokine-like …

The chemokine chemerin is a novel adipokine involved in the regulation of energy
metabolism but also female reproductive functions in mammals. Its effects on male fertility …

Chemerin, a secreted protein mainly produced by adipocytes and hepatocytes, plays a
variety of roles in endocrine or paracrine signaling. As reported in human epidemiology …

Glucagon-like peptide-1 (GLP-1), secreted by intestinal L-cells, plays a pivotal role in the
modulation of β-cell insulin secretion in a glucose-dependent manner, concurrently …

Objective It was reported that chemerin as an adipocyte-secreted protein could regulate
bone resorption and bone formation. However, the specific molecular and gene mechanism …