Mouse models in colon cancer, inferences, and implications
MH Kucherlapati - Iscience, 2023 - cell.com
Mouse models of colorectal cancer (CRC) have been crucial in the identification of the role
of genes responsible for the full range of pathology of the human disease and have proved …
of genes responsible for the full range of pathology of the human disease and have proved …
Fungal symbiont transmitted by free-living mice promotes type 2 immunity
The gut mycobiota is crucial for intestinal homeostasis and immune function. Yet its
variability and inconsistent fungal colonization of laboratory mice hinders the study of the …
variability and inconsistent fungal colonization of laboratory mice hinders the study of the …
[HTML][HTML] MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses
Although intestinal epithelial cells (IECs) can express major histocompatibility complex class
II (MHC II), especially during intestinal inflammation, it remains unclear if antigen …
II (MHC II), especially during intestinal inflammation, it remains unclear if antigen …
Specialized mechanosensory epithelial cells in mouse gut intrinsic tactile sensitivity
AJ Treichel, I Finholm, KR Knutson, C Alcaino… - Gastroenterology, 2022 - Elsevier
Background and Aims The gastrointestinal (GI) tract extracts nutrients from ingested meals
while protecting the organism from infectious agents frequently present in meals …
while protecting the organism from infectious agents frequently present in meals …
Surf4 (Surfeit Locus Protein 4) deficiency reduces intestinal lipid absorption and secretion and decreases metabolism in mice
G Tao, H Wang, Y Shen, L Zhai, B Liu… - … and Vascular Biology, 2023 - Am Heart Assoc
Background: Postprandial dyslipidemia is a causative risk factor for cardiovascular disease.
The majority of absorbed dietary lipids are packaged into chylomicron and then delivered to …
The majority of absorbed dietary lipids are packaged into chylomicron and then delivered to …
Enteroendocrine cell lineages that differentially control feeding and gut motility
Enteroendocrine cells are specialized sensory cells of the gut-brain axis that are sparsely
distributed along the intestinal epithelium. The functions of enteroendocrine cells have …
distributed along the intestinal epithelium. The functions of enteroendocrine cells have …
Glycans that regulate Notch signaling in the intestine
Intestinal homeostasis is key to the maintenance of good health. The small intestine plays
important roles in absorption, digestion, hormonal and immune functions. Crypt base …
important roles in absorption, digestion, hormonal and immune functions. Crypt base …
The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse
The Thiamine Transporter 2 (THTR2) encoded by SLC19A3 plays an ill-defined role in the
maintenance of tissue thiamine, thiamine monophosphate, and thiamine diphosphate (TDP) …
maintenance of tissue thiamine, thiamine monophosphate, and thiamine diphosphate (TDP) …
[HTML][HTML] RBM47 regulates intestinal injury and tumorigenesis by modifying proliferation, oxidative response, and inflammatory pathways
S Soleymanjahi, V Blanc, EA Molitor, DM Alvarado… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract RNA-binding protein 47 (RBM47) is required for embryonic endoderm
development, but a role in adult intestine is unknown. We studied intestine-specific Rbm47 …
development, but a role in adult intestine is unknown. We studied intestine-specific Rbm47 …
Cannabinoid CB1 Receptors in the Intestinal Epithelium Are Required for Acute Western-Diet Preferences in Mice
The endocannabinoid system plays an important role in the intake of palatable food. For
example, endocannabinoid signaling in the upper small-intestinal epithelium is increased (i) …
example, endocannabinoid signaling in the upper small-intestinal epithelium is increased (i) …