Alcohol use disorder remains a substantial social, health, and economic problem and
problem drinking levels in women have been increasing in recent years. Understanding …

The neuropeptide hypocretin/orexin plays a broad and important role in physiological
functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and …

Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder
(AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with …

Background There is a serious public health need for better understanding of alcohol use
disorder disease mechanisms and for improved treatments. At this writing, only three drugs …

Alcohol use disorder exhausts substantial social and economic costs, with recent dramatic
increases in female problem drinking. Thus, it is critically important to understand signaling …

Excessive, binge alcohol drinking is a potent and pernicious obstacle to treating alcohol use
disorder (AUD), and heavy-drinking humans are responsible for much of the substantial …

Addiction to alcohol remains a major social and economic problem, in part because of the
high motivation for alcohol that humans exhibit and the hazardous binge intake this …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase associated with alcohol
dependence in humans and behavioral responses to ethanol in mice. To characterize the …

Introductions Binge drinking is a deadly pattern of alcohol consumption. Evidence suggests
that genetic variation in clock genes is strongly associated with alcohol misuse; however, the …

Systemic administration of the orthosteric agonist, baclofen, and several positive allosteric
modulators (PAMs) of the GABA B receptor has repeatedly been reported to decrease …