Involvement of actin and actin-binding proteins in carcinogenesis

M Izdebska, W Zielińska, M Hałas-Wiśniewska… - Cells, 2020 - mdpi.com
The actin cytoskeleton plays a crucial role in many cellular processes while its
reorganization is important in maintaining cell homeostasis. However, in the case of cancer …

CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis

JM Peng, SH Lin, MC Yu… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Membrane protrusion and adhesion to the extracellular matrix, which involves the extension
of actin filaments and formation of adhesion complexes, are the fundamental processes for …

The unusual suspects in cytokinesis: Fitting the pieces together

LTS Nguyen, DN Robinson - Frontiers in cell and developmental …, 2020 - frontiersin.org
Cytokinesis is the step of the cell cycle in which the cell must faithfully separate the
chromosomes and cytoplasm, yielding two daughter cells. The assembly and contraction of …

CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function

DY Mao, ML Kleinjan, I Jilishitz, B Swaminathan… - Science …, 2021 - science.org
Chloride intracellular channels 1 (CLIC1) and 4 (CLIC4) are expressed in endothelial cells
and regulate angiogenic behaviors in vitro, and the expression of Clic4 is important for …

CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis

ZCU Kagiali, N Saner, M Akdag, E Sanal… - Life science …, 2020 - life-science-alliance.org
CLIC4 and CLIC1 are members of the well-conserved chloride intracellular channel proteins
(CLICs) structurally related to glutathione-S-transferases. Here, we report new roles of …

mDia1 assembles a linear F-actin coat at membrane invaginations to drive Listeria monocytogenes cell-to-cell spreading

AS Dhanda, AW Vogl, F Ness, M Innocenti, JA Guttman - Mbio, 2021 - Am Soc Microbiol
Direct cell-to-cell spreading of Listeria monocytogenes requires the bacteria to induce actin-
based finger-like membrane protrusions in donor host cells that are endocytosed through …

CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division

E Peterman, M Valius, R Prekeris - Journal of cell science, 2020 - journals.biologists.com
During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic
changes that play key roles in progression through mitosis. Although the regulators of …

Proteomics Analysis of Pregnancy in Ewes under Heat Stress Conditions and Melatonin Administration

E Bouroutzika, S Proikakis, EK Theodosiadou… - Animals, 2024 - mdpi.com
Simple Summary Heat stress is known to cause disruptions to a variety of physiological
processes in sheep, including reproduction and ultimately pregnancy, mostly by promoting …

A metazoan-specific C-terminal motif in EXC-4 and Gα-Rho/Rac signaling regulate cell outgrowth during tubulogenesis in C. elegans

AF Arena, J Escudero, DD Shaye - Development, 2022 - journals.biologists.com
Chloride intracellular channels (CLICs) are conserved proteins for which the cellular and
molecular functions remain mysterious. An important insight into CLIC function came from …

Global acetylome profiling indicates EPA impedes but OA promotes prostate cancer motility through altered acetylation of PFN1 and FLNA

C He, X Chen, Y Chen, J Sun, M Qi, S Rocha… - …, 2024 - Wiley Online Library
Prostate cancer (PCa) is one of the leading causes of cancer morbidity and mortality in men.
Metastasis is the main cause of PCa‐associated death. Recent evidence indicated a …