New chemistries and enzymes for synthetic genetics
Beyond the natural nucleic acids DNA and RNA, nucleic acid chemistry has unlocked a
whole universe of modifications to their canonical chemical structure, which can in various …
whole universe of modifications to their canonical chemical structure, which can in various …
Interactions of small molecules with DNA junctions
The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …
High‐Strength and Injectable Supramolecular Hydrogel Self‐Assembled by Monomeric Nucleoside for Tooth‐Extraction Wound Healing
Z Wang, Y Zhang, Y Yin, J Liu, P Li, Y Zhao… - Advanced …, 2022 - Wiley Online Library
Hydrogels with high mechanical strength and injectability have attracted extensive attention
in biomedical and tissue engineering. However, endowing a hydrogel with both properties is …
in biomedical and tissue engineering. However, endowing a hydrogel with both properties is …
Harnessing non-Watson–Crick's base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells
Genomic DNA of the cyanophage S-2L virus is composed of 2-aminoadenine (Z), thymine
(T), guanine (G), and cytosine (C), forming the genetic alphabet ZTGC, which violates …
(T), guanine (G), and cytosine (C), forming the genetic alphabet ZTGC, which violates …
Reclassification of family A DNA polymerases reveals novel functional subfamilies and distinctive structural features
D Czernecki, A Nourisson, P Legrand… - Nucleic Acids …, 2023 - academic.oup.com
Abstract Family A DNA polymerases (PolAs) form an important and well-studied class of
extant polymerases participating in DNA replication and repair. Nonetheless, despite the …
extant polymerases participating in DNA replication and repair. Nonetheless, despite the …
Assessing readability of an 8-letter expanded deoxyribonucleic acid alphabet with nanopores
Chemists have now synthesized new kinds of DNA that add nucleotides to the four standard
nucleotides (guanine, adenine, cytosine, and thymine) found in standard Terran DNA. Such …
nucleotides (guanine, adenine, cytosine, and thymine) found in standard Terran DNA. Such …
Hypermodified DNA in Viruses of E. coli and Salmonella
The DNA in bacterial viruses collectively contains a rich, yet relatively underexplored,
chemical diversity of nucleobases beyond the canonical adenine, guanine, cytosine, and …
chemical diversity of nucleobases beyond the canonical adenine, guanine, cytosine, and …
Anaerobic phloroglucinol degradation by Clostridium scatologenes
Y Zhou, Y Wei, L Jiang, X Jiao, Y Zhang - Mbio, 2023 - Am Soc Microbiol
Polyphenols are abundant in nature, and their anaerobic biodegradation by gut and soil
bacteria is a topic of great interest. The O2 requirement of phenol oxidases is thought to …
bacteria is a topic of great interest. The O2 requirement of phenol oxidases is thought to …
Detection of nucleotide modifications in bacteria and bacteriophages: Strengths and limitations of current technologies and software
RNA and DNA modifications occur in eukaryotes and prokaryotes, as well as in their viruses,
and serve a wide range of functions, from gene regulation to nucleic acid protection …
and serve a wide range of functions, from gene regulation to nucleic acid protection …
Stability of nucleic acid bases in concentrated sulfuric acid: Implications for the habitability of Venus' clouds
S Seager, JJ Petkowski, MD Seager… - Proceedings of the …, 2023 - National Acad Sciences
What constitutes a habitable planet is a frontier to be explored and requires pushing the
boundaries of our terracentric viewpoint for what we deem to be a habitable environment …
boundaries of our terracentric viewpoint for what we deem to be a habitable environment …