1928 Circulation October 22, 2013 mental health, functional status, activity limitations,
cancerrelated pain, and cancer-related anxiety) declined moderately to severely in 44%. 5 …

The number of patients surviving≥ 5 years after initial cancer diagnosis has significantly
increased during the last decades due to considerable improvements in the treatment of …

The demography of differentiated thyroid cancers (DTCs) has changed considerably since
the 1990s, when the vast majority of these tumors were clinically evident at the time of …

Growth hormone (GH) is a peptide hormone secreted from the pituitary gland under the
control of the hypothalamus. It has a many actions in the body, including regulating a …

Survival rates are improving following cancer therapy for childhood brain tumours. There is
therefore a growing cohort of survivors at risk of late effects of cancer therapy. Endocrine …

Context Data on hypothalamic-pituitary (HP) disorders in systematically evaluated childhood
cancer survivors are limited. Objective To describe prevalence, risk factors, and associated …

Context: Hypothalamic-pituitary (HP) dysfunction is common in children treated with cranial
radiotherapy (RT) for brain tumors, but there is little known about the risk of HP dysfunction …

Context: GH and IGF-1 have been shown to affect tumor growth in vitro and in some animal
models. This report summarizes the available evidence on whether GH therapy in childhood …

Subtle to frank abnormalities in hypothalamic–pituitary axis function are frequently seen in
cancer survivors who have received prophylactic or therapeutic cranial irradiation. The …

Over the past decades, survival rates of childhood cancer have increased considerably from
5 to 30% in the early seventies to current rates exceeding 80%. This is due to the …