Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

Physical properties of nanoparticles that result in improved cancer targeting

R Zein, W Sharrouf, K Selting - Journal of Oncology, 2020 - Wiley Online Library
The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target,
and drug penetration into tumors is limited by abnormal vasculature and high interstitial …

Impairing Tumor Metabolic Plasticity via a Stable Metal‐Phenolic‐Based Polymeric Nanomedicine to Suppress Colorectal Cancer

X Li, Z Duan, X Chen, D Pan, Q Luo, L Gu… - Advanced …, 2023 - Wiley Online Library
Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However,
the therapeutic efficacy of existing metabolism‐regulating agents is often compromised due …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

[HTML][HTML] Polymer bioconjugates: Modern design concepts toward precision hybrid materials

C Chen, DYW Ng, T Weil - Progress in Polymer Science, 2020 - Elsevier
The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …

A pH‐triggered self‐unpacking capsule containing zwitterionic hydrogel‐coated MOF nanoparticles for efficient oral exendin‐4 delivery

Y Zhou, Z Chen, D Zhao, D Li, C He… - Advanced …, 2021 - Wiley Online Library
Oral peptide or protein delivery is considered a revolutionary alternative to daily
subcutaneous injection; however, major challenges remain in terms of impediments of the …

Stimuli‐sensitive linear–dendritic block copolymer–drug prodrug as a nanoplatform for tumor combination therapy

H Cai, P Tan, X Chen, M Kopytynski, D Pan… - Advanced …, 2022 - Wiley Online Library
Linear–dendritic block copolymer (LDBCs) are highly attractive candidates for smart drug‐
delivery vehicles. Herein, an amphiphilic poly [(ethylene glycol) methyl ether methacrylate] …

Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review

K Shiraishi, M Yokoyama - Science and technology of advanced …, 2019 - Taylor & Francis
Polymeric-micelle carrier systems have emerged as a novel drug-carrier system and have
been actively studied for anticancer drug targeting. In contrast, toxicological and …

Confinement of therapeutic enzymes in selectively permeable polymer vesicles by polymerization-induced self-assembly (PISA) reduces antibody binding and …

LD Blackman, S Varlas, MC Arno, ZH Houston… - ACS central …, 2018 - ACS Publications
Covalent PEGylation of biologics has been widely employed to reduce immunogenicity,
while improving stability and half-life in vivo. This approach requires covalent protein …

A breathing atom‐transfer radical polymerization: fully oxygen‐tolerant polymerization inspired by aerobic respiration of cells

AE Enciso, L Fu, AJ Russell… - Angewandte Chemie …, 2018 - Wiley Online Library
The first well‐controlled aqueous atom‐transfer radical polymerization (ATRP) conducted in
the open air is reported. This air‐tolerant ATRP was enabled by the continuous conversion …