The reactive functionalities of drugs that engage in covalent interactions with the
enzyme/receptor residue in either a reversible or an irreversible manner are …

New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …

In some parts of the world, Cyperus esculentus L. is widely used as a healthy food for both
humans and animals due to their nutritional and functional properties. Current research and …

The divergent sequences, protein structures, and catalytic mechanisms of serine-and
metallo-β-lactamases hamper the development of wide-spectrum β-lactamase inhibitors that …

Aberrant protein citrullination is associated with many pathologies; however, the specific
effects of this modification remain unknown. We have previously demonstrated that serine …

Most efforts in the development of antimicrobials have focused on the screening of lethal
targets. Nevertheless, the constant expansion of antimicrobial resistance makes the …

To counter the emergence of β-lactamase (BL) mediated resistance, design of new β-
lactamase inhibitors (BLIs) is critical. Many high-resolution crystallographic structures of BL …

Objective To evaluate the safety profile and antioxidant activity of fatty hydroxamic acid
(FHA) from the seed oil of Cyperus esculentus (C. esculentus). Methods FHA was …

O-Aryloxycarbonyl hydroxamates have previously been shown to efficiently inactivate class
C β-lactamases by cross-linking serine and lysine residues in the active site. A new …

β-Lactamase inhibitors are important in medicine in the protection of β-lactam antibiotics
from β-lactamase-catalyzed destruction. The most effective inhibitors of serine β-lactamases …