The available information on the world distribution of Huntington's disease (HD) from
population surveys and death rate analysis is summarised and discussed in the light of …

The Huntington disease gene was mapped to human chromosome 4p in 1983 and 10 years
later the pathogenic mutation was identified as a CAG-repeat expansion. Our current …

The Huntington's disease (HD) gene has been mapped in 4p16. 3 but has eluded
identification. We have used haplotype analysis of linkage disequilibrium to spotlight a small …

The molecular analysis of a specific CAG repeat sequence in the Huntington's disease gene
in 440 Huntington's disease patients and 360 normal controls reveals a range of 30–70 …

In the last few years there have been rapid advances in developing genetic maps for
humans, greatly enhancing our ability to localize and identify genes for inherited disorders …

Huntington's disease is an inherited disorder in which selective neuronal loss in the brain
leads to a characteristic choreic movement disorder. The successful mapping of the …

Abstract Analysis of 78 Huntington's disease (HD) chromosomes with multi–allele markers
revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The …

Telomeres, at the ends of chromosomes and strands of genetic material, become shorter as
cells divide in the process of aging. Telomere length has been considered as a biological …

Linkage-disequilibrium mapping (LDM) recently has been hailed as a powerful statistical
method for fine-scale mapping of disease genes. After reviewing its historical background …

The gene responsible for Huntington disease (HD), an autosomal dominant
neurodegenerative disorder, is located near the terminus of the short arm of chromosome 4 …