The newly proposed glioma stem cell (GSC) hypothesis may re‐model the way we diagnose
and treat the tumor, which highlights the need for a complete knowledge on the genetic and …

Background The growth and recurrence of several cancers appear to be driven by a
population of cancer stem cells (CSCs). Glioblastoma, the most common primary brain …

Glioblastoma remains a tumor with a dismal prognosis because of failure of current
treatment. Glioblastoma cells with stem cell (GSC) properties survive chemotherapy and …

Background Glioblastomas are invasive therapy resistant brain tumors with extremely poor
prognosis. The Glioma initiating cell (GIC) population contributes to therapeutic resistance …

Background A major barrier to effective treatment of glioblastoma (GBM) is the large
intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials …

Glioblastoma (GBM) is both the most common and the most lethal primary brain tumor. It is
thought that GBM stem cells (GSCs) are critically important in resistance to therapy …

Glioblastoma is the most common brain tumor. Median survival in unselected patients is< 10
months. The tumor harbors stem-like cells that self-renew and propagate upon serial …

Formation of glioma stem cells (GSCs) is considered as one of the main reasons of
temozolomide (TMZ) resistance in glioma patients. Recent studies have shown that tumor …

Purpose Constructed from a theoretical framework, the coordinated undermining of survival
paths in glioblastoma (GBM) is a combination of nine drugs approved for non-oncological …

Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma.
Cell therapy may provide a promising treatment for TBI. Among different cell types, human …